Selectivity in micellar chromatography using a zwitterionic surfactant
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Updated: Oct 22, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Abstract:
This work discusses the effects of neutral zwitterionic micelles composed of N-dodecyl-N,N-dimethylammonium-3-propane-1-sulfonate (C12DAPS) on the retention of several substituted benzene compounds. The correlation of molecular properties and retention demonstrates that negative charge, hydrophobicity, and polarizability are important in governing a solute's distribution in the micelles. The selectivity of the micelles differs from that of the native reversed-phase stationary phase, especially for nitrophenol isomers and halobenzenes.
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