Epidemiological Study of Parental Obstructive Sleep Apnea and Subsequent Risk of ADHD in Their Children: A Nationwide

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Iwen Chen1, Jing-Yang Huang2, Renin Chang1

  • 1Kaohsiung Veterans General Hospital.

Journal of Attention Disorders
|September 16, 2022
PubMed

Insights

Parental obstructive sleep apnea (OSA) may increase the risk of attention-deficit/hyperactivity disorder (ADHD) in children. This study found a significant association between parental OSA and offspring ADHD, suggesting a potential link requiring further investigation.

Area of Science:

  • Pediatric Neurology
  • Sleep Medicine
  • Genetics and Genomics

Background:

  • Obstructive sleep apnea (OSA) is linked to systemic inflammation and oxidative stress.
  • These physiological changes may impact neurodevelopmental outcomes in children.

Purpose of the Study:

  • To investigate the association between parental obstructive sleep apnea (OSA) and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring.
  • To explore potential links between parental sleep disorders and neurodevelopmental conditions in children.

Main Methods:

  • A nested case-control study utilizing Taiwan's National Birth Registry and National Health Insurance Research Database (2006-2015).
  • Included 1,723,873 singleton live births, comparing children with ADHD to matched controls.
  • Conditional logistic regression analysis was used to determine adjusted odds ratios (aOR).

Main Results:

  • Offspring ADHD risk was elevated with paternal OSA (aOR: 1.758) and maternal OSA (aOR: 2.159).
  • Subgroup analyses indicated varying effects of parental diseases based on the child's gender.

Conclusions:

  • Parental OSA is associated with an increased risk of ADHD in children.
  • Further research is warranted to elucidate the underlying mechanisms connecting parental OSA and childhood ADHD.
Abstract

Keywords:
ADHDcase control studygender effectparental obstructive sleep apnea

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