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Alterations of static and dynamic functional network connectivity in acute ischemic brainstem stroke
1Department of Radiology, 372209Taizhou People's Hospital, Fifth Affiliated Hospital of Nantong University, Taizhou, Jiangsu, PR China.
Acta Radiologica (Stockholm, Sweden : 1987)
|September 16, 2022
Summary
Acute brainstem stroke disrupts brain networks, affecting both static and dynamic functional connectivity (FNC). This study reveals widespread FNC abnormalities in patients, offering new insights into stroke-related network changes.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurology
Background:
- Abnormal brain functional network changes are documented in ischemic stroke patients.
- Dynamic functional network connectivity (FNC) alterations in brainstem strokes remain unclear.
Purpose of the Study:
- To evaluate static and dynamic FNC changes in acute brainstem ischemic stroke.
- To correlate these FNC alterations with upper limb motor function.
Main Methods:
- Resting-state functional magnetic resonance imaging (rs-fMRI) on 50 acute brainstem stroke patients and 50 controls.
- Independent component analysis to assess static and dynamic FNC across seven key resting-state networks.
- Analysis included the default mode network (DMN), executive control network (ECN), and others.
Main Results:
- Patients showed significant static FNC aberrations compared to controls, with increased connectivity in several network pairs (e.g., DMN-ECN).
- Dynamic FNC alterations were observed in specific states, including increased DMN-AN and DMN-ECN connectivity and decreased SMN-VN connectivity in State 1.
- State 5 revealed increased DMN-VN and AN-AUN connectivity, alongside decreased AN-SMN connectivity.
Conclusions:
- Acute brainstem ischemic stroke is associated with significant impairments in both static and dynamic functional network connectivity.
- These findings broaden the understanding of stroke's impact on brain networks from both static and dynamic viewpoints.
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