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Cerebral perfusion in untreated, controlled, and uncontrolled hypertension

Isabel N Christie1, Rowan Windsor1, Henk Jmm Mutsaerts2

  • 1Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|September 16, 2022
PubMed

Insights

High blood pressure is linked to reduced brain blood flow. Controlling hypertension is crucial for maintaining healthy cerebral perfusion and brain health.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Medical Imaging

Background:

  • Systemic arterial blood pressure is a critical factor influencing cerebral perfusion.
  • Hypertension is a prevalent condition associated with various health risks, including cerebrovascular complications.
  • Understanding the relationship between blood pressure and brain blood flow is essential for preventative strategies.

Purpose of the Study:

  • To investigate the association between systemic arterial blood pressure and cerebral blood flow (CBF).
  • To evaluate the impact of hypertension and its treatment on cerebral perfusion.
  • To determine the significance of blood pressure control in maintaining brain health.

Main Methods:

  • Utilized data from 740 participants in a large-scale tri-ethnic study in the UK.
  • Measured cerebral blood flow (CBF) using arterial spin labelling magnetic resonance imaging (ASL MRI).
  • Analyzed correlations between blood pressure, age, and CBF.

Main Results:

  • A significant negative correlation was observed between blood pressure, age, and CBF.
  • The lowest CBF values were found in hypertensive patients with uncontrolled blood pressure despite medication.
  • Hypertension is confirmed to be associated with reduced cerebral perfusion.

Conclusions:

  • Elevated blood pressure is linked to diminished cerebral perfusion.
  • Effective blood pressure management is vital for preserving brain blood flow.
  • This study underscores the importance of controlling hypertension to protect brain health.

Keywords:
Cerebral blood flowMRIbrainhypertensionperfusion

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