Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

971
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
971
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.5K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history, and potential treatments from translation to clinical trials.

Frontiers in stroke·2026
Same author

Osteosclerosis and Meningioma: Implicating the Tumor Suppressor Gene <i>AMER1/WTX</i>.

Anticancer research·2025
Same author

How is rosette formation in brain tumours linked with cerebrospinal fluid spread?

Brain tumor pathology·2025
Same author

The deleterious effect of WHO grade II diffuse glioma on socioeconomic status as evaluated through occupation.

Scientific reports·2025
Same author

Community-acquired cerebral abscess and intracranial empyemas in children: a prospective cohort study.

Journal of neurosurgery. Pediatrics·2025
Same author

Enhancing the therapeutic efficacy of tumor-treating fields (TTFields): further perspectives.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2025

Related Experiment Video

Updated: Aug 28, 2025

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
06:24

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

3.5K

Does covid-19 impair endogenous neurogenesis?

Ashwin Kumaria1, Abiodun Noah2, Matthew A Kirkman1

  • 1Department of Neurosurgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|September 16, 2022
PubMed
Summary

The SARS-CoV-2 virus may impair neural stem cell activity, reducing neurogenesis. This could explain brain changes and neurodegeneration seen in COVID-19 and long COVID.

Keywords:
Brain tumourCOVID-19CognitionGliomaNeurodegenerative diseasesNeurogenesisOlfaction

More Related Videos

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.3K
Methods for the Modulation and Analysis of NF-&#954;B-dependent Adult Neurogenesis
14:58

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

14.4K

Related Experiment Videos

Last Updated: Aug 28, 2025

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
06:24

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

3.5K
Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.3K
Methods for the Modulation and Analysis of NF-&#954;B-dependent Adult Neurogenesis
14:58

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

14.4K

Area of Science:

  • Neuroscience
  • Virology
  • Stem Cell Biology

Background:

  • Endogenous neural stem cells generate neurons throughout life, supporting olfaction, cognition, learning, and memory.
  • COVID-19 (caused by SARS-CoV-2) is associated with impaired olfaction, cognition, and emerging evidence suggests accelerated neurodegeneration and brain structure changes.

Purpose of the Study:

  • To hypothesize that SARS-CoV-2 infection impairs endogenous neural stem cell activity and neurogenesis.
  • To explore the role of attenuated neurogenesis in COVID-19-related brain changes, neurodegeneration, and long COVID.
  • To consider therapeutic strategies targeting neural stem cells for COVID-19 neurological sequelae and glioma treatment.

Main Methods:

  • This study is primarily a hypothesis-driven review and theoretical exploration.
  • It synthesizes existing evidence on neurogenesis, SARS-CoV-2 infection, and neurological outcomes.
  • It proposes a mechanism linking viral infection to stem cell dysfunction.

Main Results:

  • The hypothesis posits that SARS-CoV-2 may attenuate endogenous neural stem cell activity.
  • This attenuation could lead to reduced neurogenesis, contributing to brain size reduction and neurodegeneration.
  • Potential implications for glioma development and long COVID are considered.

Conclusions:

  • Impaired neurogenesis due to SARS-CoV-2 infection is a plausible mechanism for neurological deficits in COVID-19.
  • Understanding this interaction may reveal novel therapeutic targets for neurological manifestations and glioma.
  • Modulating neurogenesis could be a future treatment strategy for long COVID neurological symptoms.