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Catherine M Phelps1, Marlies Meisel2
1Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cell
|September 16, 2022
Summary
Altered gut bacteria are linked to multiple sclerosis (MS) development. A large study profiled the gut microbiome
Area of Science:
- Microbiome research
- Neuroimmunology
- Complex disease etiology
Background:
- Gut microbiota alterations are implicated in the development of complex diseases.
- Multiple sclerosis (MS) is a complex neurological disease with suspected links to the gut microbiome.
Purpose of the Study:
- To investigate the role of the gut microbiome in multiple sclerosis pathogenesis.
- To profile the composition and function of the gut microbiome in MS patients.
Main Methods:
- A multi-omics approach was utilized.
- An extensive cohort of MS patients was studied.
- Gut microbiome composition and function were analyzed.
Main Results:
- The study profiled the gut microbiome in a large group of MS patients.
- Composition and functional aspects of the gut microbiome were analyzed.
Conclusions:
- The gut microbiome is associated with the etiopathogenesis of multiple sclerosis.
- Further research into the MS microbiome is warranted.
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