Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Premedication with lorazepam before bone marrow biopsy.

D W Milligan, M R Howard, A Judd

    Journal of Clinical Pathology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    'Learning from post COVID-19 condition for epidemic preparedness'-author's response.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025
    Same author

    Arterial Stiffness in a Cohort of Young People Living With Perinatal HIV and HIV Negative Young People in England.

    Frontiers in cardiovascular medicine·2022
    Same author

    Mortality and AIDS-defining events among young people following transition from paediatric to adult HIV care in the UK.

    HIV medicine·2021
    Same author

    A hypothesis for the existence of two types of tuberculosis, reflecting two distinct types of immune failure to control the pathogen, based upon prevalence of mycobacterium-specific IgG subclasses.

    Scandinavian journal of immunology·2018
    Same author

    Tuberculosis in HIV-infected children in Europe, Thailand and Brazil: paediatric TB-HIV EuroCoord study.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2016
    Same author

    Higher rates of triple-class virological failure in perinatally HIV-infected teenagers compared with heterosexually infected young adults in Europe.

    HIV medicine·2016

    Lorazepam (4 mg) effectively reduced pain recall 24 hours after bone marrow biopsy. This study found lorazepam useful for reducing patient discomfort and improving recall after the procedure.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Bone marrow aspiration and trephine biopsy are painful procedures.
    • Effective pain management and anxiolysis are crucial for patient comfort during invasive procedures.

    Purpose of the Study:

    • To evaluate the efficacy of lorazepam as a premedication for bone marrow aspiration and trephine biopsy.
    • To assess the impact of lorazepam on pain perception and recall post-procedure.

    Main Methods:

    • A double-blind, placebo-controlled study involving 50 randomized patients.
    • Patients received either lorazepam (4 mg orally) or a placebo before the procedure.
    • Pain was assessed using a visual analogue linear pain scale immediately after and 24 hours post-procedure.

    Main Results:

    Related Experiment Videos

    • No significant difference in immediate post-procedure pain recall between lorazepam and placebo groups.
    • Significant reduction (60%) in pain scale scores 24 hours later in the lorazepam group (p < 0.01).
    • 36% of patients receiving lorazepam had no recall of the procedure 24 hours later, with no amnesic effect in the placebo group.

    Conclusions:

    • Lorazepam (4 mg orally) is a useful premedication agent for bone marrow biopsy.
    • It significantly reduces delayed pain recall and induces amnesia for the procedure.
    • Few side effects were reported, suggesting a favorable safety profile.