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Experimental tooth loss affects spatial learning function and blood-brain barrier of mice
Hiroshi Oue1, Rie Hatakeyama1, Eri Ishida1
1Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Oral Diseases
|September 17, 2022
Summary
Experimental tooth loss in mice impaired learning and memory functions over time. This was linked to reduced claudin-5 levels and brain inflammation, suggesting a connection between tooth loss and cognitive decline.
Area of Science:
- Neuroscience
- Oral Health Research
- Cognitive Science
Background:
- Tooth loss is a common issue with potential systemic health implications.
- The impact of tooth loss on cognitive function and brain pathophysiology remains underexplored.
Purpose of the Study:
- To investigate the effects of experimental tooth loss on learning, memory, and brain changes in mice.
- To explore the relationship between tooth loss and cognitive dysfunction.
Main Methods:
- Mice underwent tooth extraction and were compared to a control group.
- Behavioral tests were conducted at 6 and 12 months post-extraction.
- Brain tissue analysis included tight junction protein levels (claudin-5) and hippocampal astrogliosis.
Main Results:
- No significant differences were observed at 6 months.
- At 12 months, tooth loss mice showed longer escape latencies, indicating impaired learning.
- Reduced claudin-5 levels and increased hippocampal astrogliosis were found in the tooth loss group.
Conclusions:
- Experimental tooth loss leads to impaired learning and memory in mice.
- Tooth loss is associated with decreased claudin-5 and hippocampal astrogliosis.
- Findings suggest a link between tooth loss and cognitive dysfunction.
