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Updated: Aug 28, 2025

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
Published on: May 31, 2024
Histologic Activity in an Endoscopically Normal-Appearing Pouch Predicts Future Risk of Pouchitis in Patients With
Akshita Gupta1, Jennifer F N Kizza2, Ashwin N Ananthakrishnan1,3
1Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Introduction:
The impact of histologic inflammation on subsequent risk of acute pouchitis in patients with ulcerative colitis (UC) has not been robustly examined.
Methods:
We examined the association between histologic inflammation in endoscopically normal-appearing ileal pouches in patients with UC with subsequent risk of antibiotic-responsive acute pouchitis.
Results:
Among 163 study patients, 53% had histologic inflammation in an endoscopically normal-appearing ileal pouch. Histologic inflammation in the pouch was associated with an increased risk of pouchitis (24.1% vs 6.8%, adjusted odds ratio 4.41, 95% confidence interval 1.48-13.20).
Discussion:
Histologic inflammation in an endoscopically normal pouch was associated with an increased risk of acute pouchitis.
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