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Potential nanocarrier-mediated miRNA-based therapy approaches for multiple sclerosis

K Trideva Sastri1, N Vishal Gupta1, Anbarasu Kannan2

  • 1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Shivarathreeshwara Nagara, Bannimantap, Mysuru, India.

Drug Discovery Today
|September 17, 2022
PubMed

Insights

This review explores using nanoformulations to deliver microRNAs (miRNAs) for managing multiple sclerosis (MS). Nanocarrier systems offer a promising therapeutic strategy for this autoimmune neuroinflammatory disorder.

Area of Science:

  • Neuroscience
  • Immunology
  • Biotechnology

Background:

  • Multiple sclerosis (MS) is an autoimmune neuroinflammatory disease characterized by neurodegeneration and demyelination.
  • MicroRNAs (miRNAs) play a critical role in the biological processes underlying MS pathogenesis.
  • Current therapeutic strategies for MS face challenges in effectively targeting the underlying molecular mechanisms.

Purpose of the Study:

  • To review the potential of microRNA (miRNA) delivery using nanoformulations for managing multiple sclerosis (MS).
  • To discuss miRNA synthesis, dysregulation in MS, and formulation strategies for nanocarrier-based delivery.
  • To highlight the therapeutic benefits of advanced nanotechnologies in MS management.

Main Methods:

  • Literature review focusing on miRNA biology in MS.
  • Analysis of nanoformulation strategies for miRNA delivery.
  • Evaluation of nanocarrier systems for therapeutic applications in MS.

Main Results:

  • Evidence supports miRNA dysregulation in the pathogenesis of multiple sclerosis.
  • Nanoformulations provide a feasible approach for targeted miRNA delivery in MS.
  • Various nanocarrier systems show potential for enhancing therapeutic efficacy in MS.

Conclusions:

  • MicroRNA-based therapies hold promise for treating multiple sclerosis.
  • Nanotechnology offers innovative solutions for effective miRNA delivery in MS.
  • Further research into nanoformulated miRNAs could lead to improved MS management strategies.
Keywords:
Multiple sclerosisNanocarrier systemsRecent studiesmiRNA-based therapies

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