Related Experiment Video

Updated: Aug 28, 2025

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.4K

Posterior segment complications and the risk factors after allogeneic hematopoietic stem cell transplantation

Boyu Yang1, Shaowen Wu1, Shanshan Yu1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Eye (London, England)
|September 17, 2022
PubMed

Insights

Posterior segment complications (PSC) after allogeneic hematopoietic stem cell transplantation (HSCT) are more common than previously thought. Unrelated or HLA-mismatched donors increase the risk of PSC in HSCT patients.

Area of Science:

  • Ophthalmology
  • Hematology
  • Transplantation Medicine

Background:

  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving procedure.
  • Posterior segment complications (PSC) can affect visual outcomes in HSCT recipients.
  • Understanding risk factors for PSC is crucial for patient management.

Purpose of the Study:

  • To investigate the prevalence of PSC in patients undergoing allogeneic HSCT.
  • To identify risk factors associated with the development of PSC post-HSCT.
  • To evaluate the relationship between PSC and ocular Graft-versus-Host Disease (oGVHD).

Main Methods:

  • A cross-sectional, case-control study included 143 allogeneic HSCT patients.
  • Comprehensive ocular examinations assessed PSC and oGVHD.
  • Diagnostic tools included fundus examinations, visual-evoked potential, and oGVHD scoring systems.

Main Results:

  • PSC was detected in 25.2% of patients.
  • Cytomegalovirus retinitis (9.1%) and visual pathway pathology (4.9%) were the most common PSC.
  • PSC was significantly associated with unrelated (OR=6.494) and HLA-mismatched (OR=7.193) donors.

Conclusions:

  • PSC is a notable complication following HSCT, occurring more frequently than previously recognized.
  • Ophthalmologists should be vigilant for PSC in HSCT patients.
  • Patients receiving transplants from unrelated or HLA-mismatched donors require particular attention for PSC risk.
Abstract

More Related Videos

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.2K
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.4K

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
482
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
503
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
65
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
18
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
50