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Research progress on the circRNA/lncRNA-miRNA-mRNA axis in gastric cancer
Xuemei Zeng1, Juan Xiao2, Xue Bai1
1Cancer Research Institute of Hengyang Medical School, University of South China; Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang, Hunan 421001, China.
Pathology, Research and Practice
|September 18, 2022
Summary
Gastric cancer involves genetic changes and drug resistance. This review explores the circRNA/lncRNA-miRNA-mRNA axis, a key network for early diagnosis, prognosis, and potential gastric cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gastric cancer is a prevalent global malignancy.
- Genetic and epigenetic factors drive carcinogenesis and chemotherapy resistance.
- Competing endogenous RNA (ceRNA) networks regulate gene expression.
Purpose of the Study:
- To review recent findings on the circRNA/lncRNA-miRNA-mRNA ceRNA network in gastric cancer.
- To highlight the potential of this network as diagnostic and prognostic markers.
- To explore therapeutic strategies targeting the ceRNA axis in gastric cancer.
Main Methods:
- Literature review of recent studies on gastric cancer ceRNA networks.
- Analysis of the roles of circRNAs, lncRNAs, and miRNAs in gastric cancer.
- Investigation of exosomal ncRNAs as biomarkers.
Main Results:
- The circRNA/lncRNA-miRNA-mRNA axis is implicated in gastric cancer's malignant behavior.
- Exosomal ncRNAs show promise as biomarkers for diagnosis, prognosis, and treatment.
- Specific ceRNA networks offer insights into gastric cancer progression.
Conclusions:
- The ceRNA regulatory network is crucial in gastric carcinogenesis and drug resistance.
- The circRNA/lncRNA-miRNA-mRNA axis presents potential for early diagnosis and therapy.
- Exosomal ncRNAs are valuable biomarkers for gastric cancer management.
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