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Updated: Aug 28, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Advances in Ventilator Management for Patients with Acute Respiratory Distress Syndrome
Michael C Sklar1, Laveena Munshi2
1Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Department of Anesthesiology and Pain Medicine, St. Michael's Hospital, Unity Health Toronto, 6th Floor, 30 Bond Street, Toronto M5B 1W8, Ontario, Canada; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Canada.
Abstract:
The ventilatory care of patients with acute respiratory distress syndrome (ARDS) is evolving as our understanding of physiologic mechanisms of respiratory failure improves. Despite several decades of research, the mortality rate for ARDS remains high. Over the years, we continue to expand strategies to identify and mitigate ventilator-induced lung injury. This now includes a greater understanding of the benefits and harms associated with spontaneous breathing.
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