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Related Experiment Video

Updated: Aug 28, 2025

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

Lyme Arthritis.

Sheila L Arvikar¹, Allen C Steere¹

¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, CNY149 Room 8301, 149 13th Street, Charlestown, MA 02129, USA.

Infectious Disease Clinics of North America

|September 18, 2022

Summary

This summary is machine-generated.

Lyme arthritis (LA), a common manifestation of Borrelia burgdorferi infection, presents as joint pain and swelling. While antibiotics are effective, some patients develop persistent synovitis responding to anti-inflammatory treatments.

Keywords:

Borrelia burgdorferi Inflammatory arthritis Lyme arthritis Lyme disease Postantibiotic arthritis Postinfectious arthritis

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Area of Science:

Infectious Diseases
Rheumatology
Epidemiology

Background:

Lyme arthritis (LA) is a frequent late manifestation of Borrelia burgdorferi infection in the US.
Arthritis is now the primary presenting symptom for many LA patients, often affecting large joints like the knee.
Diagnosis relies heavily on serologic testing.

Purpose of the Study:

To review the clinical presentation of Lyme arthritis.
To outline diagnostic approaches for Lyme arthritis.
To discuss management strategies for Lyme arthritis.

Main Methods:

Review of clinical presentation of Lyme arthritis.
Analysis of diagnostic methods, primarily serologic testing.
Evaluation of treatment responses and management of persistent synovitis.

Main Results:

Lyme arthritis typically presents with mono- or oligoarticular swelling and pain, predominantly in the knee.
Serologic tests are the primary diagnostic tool for Lyme arthritis.
Most patients respond well to antibiotics, but a subset develops persistent post-infectious synovitis.

Conclusions:

Lyme arthritis requires prompt diagnosis and management.
Antibiotic therapy is generally effective, but persistent synovitis may necessitate anti-inflammatory treatment.
Understanding the presentation, diagnosis, and management is crucial for optimal patient outcomes.