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Related Experiment Videos

A standardized milk tolerance test.

F P de Villiers

    Journal of Clinical Gastroenterology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    A new milk tolerance test accurately identifies lactose malabsorption and predicts symptoms. This method offers more diagnostic information than the standard lactose tolerance test for individuals with lactose intolerance.

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    Area of Science:

    • Gastroenterology
    • Human Physiology
    • Nutritional Science

    Background:

    • Lactose malabsorption, the inability to digest lactose, does not always manifest symptoms.
    • The standard lactose tolerance test identifies biochemical lactose malabsorption but not its functional impact.
    • Clinical assessment of lactose intolerance requires evaluating both malabsorption and symptom correlation.

    Purpose of the Study:

    • To compare a novel milk tolerance test with the standard lactose tolerance test.
    • To determine if the milk tolerance test can accurately identify lactose malabsorption and predict symptoms.
    • To assess the diagnostic utility of the milk tolerance test for lactose intolerance.

    Main Methods:

    • Forty healthy adult volunteers participated in the study.

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  • A milk tolerance test (500 ml milk) was compared against the standard lactose tolerance test.
  • Blood glucose rise was measured to assess lactose digestion and absorption.

    • Main Results:

    • Lactose malabsorption was indicated by a maximum glucose rise of 9 mg/100 ml or less.
    • The milk tolerance test demonstrated high diagnostic accuracy, with 100% sensitivity and 91.7% specificity compared to the standard test.
    • Only one subject was misclassified by the milk tolerance test.

    Conclusions:

    • The milk tolerance test effectively identifies individuals with lactose malabsorption.
    • This test correlates biochemical findings with likely symptom severity from milk consumption.
    • The milk tolerance test provides superior diagnostic information for lactose intolerance compared to the standard lactose tolerance test.