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[Association between body mass index and coronary heart disease in Qingdao: a prospective study]

J H Song1, C Pan1, F F Li2

  • 1Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266071, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|September 19, 2022
PubMed

Insights

Elevated body mass index (BMI) is linked to increased risks of ischemic heart disease (IHD) and major coronary events (MCE). Overweight and obesity significantly raise the likelihood of developing these serious cardiovascular conditions.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Body Mass Index (BMI) is a key indicator of weight status.
  • Coronary heart disease (CHD) remains a leading cause of mortality globally.
  • Understanding the relationship between BMI and CHD is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between Body Mass Index (BMI) and the risk of coronary heart disease.
  • To quantify the increased risk of ischemic heart disease (IHD) and major coronary events (MCE) in individuals with overweight and obesity.

Main Methods:

  • Prospective cohort study utilizing data from the China Kadoorie Biobank (CKB).
  • Inclusion of 33,355 participants aged 30-79 years.
  • Analysis of associations using multivariate Cox regression models over an average follow-up of 9.2 years.

Main Results:

  • Overweight participants showed a 41% higher risk of IHD (aHR=1.41) and 87% higher risk of MCE (aHR=1.87).
  • Obese participants exhibited a 91% higher risk of IHD (aHR=1.91) and 143% higher risk of MCE (aHR=2.43).
  • Significant associations were observed between higher BMI categories and increased cardiovascular event risks.

Conclusions:

  • Overweight and obesity are significant risk factors for developing ischemic heart disease and major coronary events.
  • Findings highlight the importance of weight management in reducing the burden of cardiovascular disease.
  • Public health initiatives targeting BMI may help mitigate coronary heart disease incidence.

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