Related Experiment Video
Updated: Aug 28, 2025
09:44
Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis
Published on: June 13, 2021
2.8K
Moonlighting proteins in medically relevant fungi
Verania J Arvizu-Rubio1, Laura C García-Carnero1, Héctor Manuel Mora-Montes1
1Department of Biology, Universidad de Guanajuato, Guanajuato, Guanajuato, Mexico.
Peerj
|September 19, 2022
Summary
Moonlighting proteins in pathogenic fungi perform multiple functions, aiding in virulence and immune evasion. Further research into these fungal proteins offers new insights into disease mechanisms.
Area of Science:
- Cell Biology
- Mycology
- Pathogenesis
Background:
- Moonlighting proteins perform multiple functions across cellular compartments, found in all life kingdoms.
- While studied in bacteria, moonlighting proteins in pathogenic fungi remain under-explored.
- Known examples in human mycoses agents include metabolic enzymes and virulence factors.
Approach:
- Review of existing literature on moonlighting proteins in pathogenic fungi.
- Identification of common moonlighting protein types and their roles.
- Analysis of their contribution to fungal pathogenesis and host interaction.
Key Points:
- Moonlighting proteins in fungi like Candida and Aspergillus have diverse roles.
- These proteins, including enolase and GAPDH, moonlight on the cell surface.
- They facilitate immune evasion, adhesion, invasion, and dissemination.
Conclusions:
- Limited data exists on moonlighting proteins in pathogenic fungi.
- These proteins represent a significant research opportunity to understand fungal pathogenesis.
- Further study will expand knowledge of fungal virulence and host interactions.
Related Concept Videos
01:28Fungal Phylum Microsporidia
95
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
95
01:28Yeast Signaling
14.8K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.8K