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Vinyl halogenated fatty acids display antibacterial activity against clinical isolates of methicillin-resistant

David J Sanabria-Rios1, Denisse Alequin-Torres2, Alenis De Jesus1

  • 1Faculty of Science and Technology, Department of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, USA.

Medical Research Archives
|September 19, 2022
PubMed

Insights

Vinyl halogenated fatty acids show promise as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). These compounds exhibit significant MRSA activity with low cytotoxicity and disrupt bacterial membranes.

Area of Science:

  • Organic Chemistry
  • Microbiology
  • Drug Discovery

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen causing severe infections.
  • MRSA's resistance to multiple antibiotics necessitates novel therapeutic strategies.
  • Vinyl halogenated fatty acids are explored for their potential antibacterial properties.

Purpose of the Study:

  • To synthesize vinyl halogenated fatty acids.
  • To evaluate their antibacterial activity against clinical MRSA isolates.
  • To investigate their mechanism of action.

Main Methods:

  • Total synthesis of vinyl halogenated fatty acids from 2-dodecynoic acid or 2-hexadecynoic acid.
  • Palladium-catalyzed coupling reaction using bis(benzonitrile)palladium (II) chloride.
  • Assessment of antibacterial activity against MRSA and cytotoxicity against Vero Cells.

Main Results:

  • Vinyl halogenated fatty acids demonstrated significant antibacterial activity against MRSA.
  • Low cytotoxicity was observed against eukaryotic Vero Cells.
  • Vinyl brominated fatty acids disrupted the S. aureus plasma membrane and inhibited norB gene expression.

Conclusions:

  • Vinyl halogenated fatty acids are effective antibacterial agents against MRSA.
  • These compounds offer a potential new class of antibiotics with a specific mechanism of action.
  • Further research into vinyl halogenated fatty acids is warranted for MRSA treatment.

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