Related Experiment Video
Updated: Aug 28, 2025
08:26
Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
15.1K
A remineralizing orthodontic etchant that utilizes calcium phosphate ion clusters
Hyeryeong Kim1, Kyung-Hyeon Yoo2, Seog-Young Yoon2
1Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, South Korea.
Frontiers in Bioengineering and Biotechnology
|September 19, 2022
Summary
A novel phosphoric acid solution with calcium phosphate ion clusters (CPICs) minimizes enamel damage during orthodontic bracket bonding. This CPIC-enhanced etchant promotes enamel remineralization and improves surface microhardness while maintaining bond strength.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Orthodontic Materials
Background:
- Orthodontic bracket bonding can lead to enamel demineralization and damage.
- Conventional phosphoric acid etching is effective for bonding but can cause surface alterations.
- Minimizing iatrogenic enamel damage during debonding is a clinical challenge.
Purpose of the Study:
- To evaluate a phosphoric acid solution incorporating calcium phosphate ion clusters (CPICs) for orthodontic bracket bonding.
- To determine if CPICs can mitigate enamel damage by promoting remineralization.
- To assess the impact of CPICs on shear bond strength (SBS) and adhesive remnant index (ARI).
Main Methods:
- Three etchants (phosphoric acid, two CPIC-incorporated solutions) and two resins were tested on 240 human premolars.
- Groups were subjected to thermocycling (TC) or not.
- Shear bond strength (SBS), adhesive remnant index (ARI), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), atomic force microscopy (AFM), and Knoop microhardness were assessed.
Main Results:
- CPIC-incorporated phosphoric acid solutions maintained SBS and reduced ARI, indicating less residual adhesive.
- SEM/EDX, element mapping, XRD, and AFM confirmed that CPIC etchants promoted enamel remineralization.
- Enamel surfaces treated with CPIC etchants showed improved roughness and microhardness compared to controls.
Conclusions:
- Phosphoric acid solutions containing CPICs effectively remineralize enamel while facilitating bracket bonding.
- CPIC-enhanced etchants offer a promising approach to minimize enamel damage during orthodontic treatment.
- This innovative approach improves enamel surface properties and reduces the risk of adhesive remnants post-debonding.
