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Phase-change materials-based platforms for biomedicine.

Biao-Qi Chen1,2, Yu-Jing Pan1, Da-Gui Zhang1

  • 1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, China.

Frontiers in Bioengineering and Biotechnology
|September 19, 2022
PubMed
Summary

Phase-change materials (PCMs) show promise in medicine for bioimaging, drug delivery, and tissue engineering. This review explores PCM platforms, addressing challenges in creating stable nanoparticles for advanced biomedical applications.

Keywords:
core-shell architecturesgatekeeperliposomesphase-change materialstemperature-controlled release

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Area of Science:

  • Biomaterials Science
  • Nanotechnology in Medicine
  • Materials Chemistry

Background:

  • Phase-change materials (PCMs) are gaining significant traction in medical applications, including bioimaging, drug delivery, and tissue engineering.
  • Their unique physicochemical and morphological properties enable the development of novel architectures for advanced therapeutic formulations.
  • Challenges exist in fabricating hydrophobic and crystalline PCMs into stable, colloidally dispersed nanoparticles.

Purpose of the Study:

  • To systematically review various phase-change material (PCM)-based platforms for biomedical applications.
  • To highlight the advantages and disadvantages of different PCM architectures (core, shell, gatekeeper) in drug delivery, bioimaging, and tissue engineering.
  • To discuss current challenges and future prospects of PCM-based biomaterials.

Main Methods:

  • Systematic review of literature on phase-change material (PCM) based platforms.
  • Analysis of PCM architectures including traditional forms (liposomes) and nanoarchitectured composites.
  • Evaluation of PCM applications in bioimaging, therapeutic delivery, and tissue engineering.

Main Results:

  • Diverse PCM-based platforms, including liposomes and nanoarchitectured composites, have been developed for biomedical uses.
  • PCMs can function as core, shell, or gatekeeper components in advanced nanoparticle designs.
  • The review highlights the suitability of these architectures for delivering bioactives, imaging, and tissue engineering.

Conclusions:

  • PCM-based platforms offer significant potential for innovative biomedical technologies and improved therapeutic formulations.
  • Overcoming challenges in nanoparticle fabrication is crucial for realizing the full potential of PCMs.
  • Future research should focus on addressing current limitations and exploring novel applications of PCM-based biomaterials.