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Cognitive Function and Vitamin D Status in the Chinese Hemodialysis Patients

Jing Zhang1, Jun Hu2, Ru Zhou1

  • 1Department of Nephrology, Wannan Medical College Affiliated Yijishan Hospital, Wuhu, Anhui Province 241001, China.

Computational and Mathematical Methods in Medicine
|September 19, 2022
PubMed

Insights

Vitamin D insufficiency is common in hemodialysis patients and linked to cognitive decline. Higher vitamin D levels (25-hydroxyvitamin D) were found to protect cognitive function in these patients.

Area of Science:

  • Nephrology
  • Neurology
  • Endocrinology

Background:

  • Cognitive function decline and vitamin D insufficiency are prevalent in hemodialysis patients.
  • Understanding the relationship between vitamin D status and cognition is crucial for this population.

Purpose of the Study:

  • To investigate the association between cognitive function and serum vitamin D levels in hemodialysis patients.
  • To determine if vitamin D status is a protective factor for cognitive function in this cohort.

Main Methods:

  • 80 hemodialysis patients were assessed using the Montreal Cognitive Assessment-Basic (MoCA-B) Chinese Version.
  • Serum 25-hydroxyvitamin D [25(OH)D] levels were measured to assess vitamin D status.
  • Statistical analyses included ANOVA, Tukey post hoc test, correlation, and regression analysis.

Main Results:

  • 35% of hemodialysis patients exhibited cognitive function decline based on MoCA-B scores.
  • A significant positive correlation was observed between serum 25(OH)D levels and MoCA-B scores (r=0.312, p=0.023).
  • The association between vitamin D levels and cognitive function was independent of demographic and clinical factors.

Conclusions:

  • Vitamin D insufficiency may contribute to cognitive impairment in patients undergoing hemodialysis.
  • Serum 25(OH)D levels serve as an independent protective factor for cognitive function in hemodialysis patients.
Abstract

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