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Updated: Aug 28, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

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Role of nuclear receptor PXR in immune cells and inflammatory diseases

Le Sun1,2,3, Zhenzhen Sun1,2,3, Qian Wang1,2,3

  • 1Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in Immunology
|September 19, 2022
PubMed

Insights

Pregnane X receptor (PXR) influences immune responses and inflammation. Targeting PXR offers potential for treating immune and inflammatory diseases.

Area of Science:

  • Molecular biology
  • Immunology
  • Pharmacology

Background:

  • Pregnane X receptor (PXR) is a nuclear receptor involved in metabolism, immune response, and inflammation.
  • The immune system protects against pathogens but dysfunction leads to diseases like infections, allergies, and autoimmune disorders.
  • Emerging evidence links PXR to the development of immune and inflammatory conditions.

Purpose of the Study:

  • To review current research on PXR's role in immunity and inflammation.
  • To discuss PXR's involvement in the pathogenesis of immune and inflammatory diseases.
  • To explore PXR as a therapeutic target for these conditions.

Main Methods:

  • Literature review of recent studies on PXR, immunity, and inflammation.
  • Analysis of PXR's mechanisms in immune regulation and inflammatory pathways.
  • Synthesis of findings to identify therapeutic potential.

Main Results:

  • PXR plays a significant role in modulating immune cell function and inflammatory signaling.
  • Dysregulation of PXR contributes to the pathology of various immune and inflammatory diseases.
  • PXR activation or inhibition shows promise in preclinical models of these disorders.

Conclusions:

  • PXR is a critical regulator of immune and inflammatory processes.
  • Targeting PXR presents a promising strategy for developing novel therapeutics for immune and inflammatory diseases.
  • Further research is warranted to fully elucidate PXR's therapeutic potential.
Keywords:
PXRdiseaseimmune cellsimmune responseinflammation

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