Emerging innovations on exosome-based onco-therapeutics

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Exosomes are nano-sized extracellular vesicles critical for intercellular communication.
• They possess inherent therapeutic properties and stability, making them suitable for clinical applications.
• Exosomes are explored for diagnosing and treating various diseases, particularly cancers.

Purpose of the Study:

• To review the therapeutic potential of exosomes in cancer management.
• To discuss current innovations and challenges in exosome-based cancer therapies.
• To explore the synergistic potential of cold atmospheric plasma with exosomes for cancer treatment.

Main Methods:

• Literature review of exosome-based cancer therapeutics.
• Analysis of exosome functionalities and stability for clinical translation.
• Exploration of cold atmospheric plasma as an adjunct therapy for exosome-based innovations.

Main Results:

• Exosomes offer a versatile platform for cancer diagnosis and therapeutics due to their stability and cargo.
• Current exosome-based strategies show promise but face challenges in clinical translation.
• Cold atmospheric plasma presents a novel approach to enhance exosome-based cancer therapies.

Conclusions:

• Exosomes hold significant potential for advancing cancer treatment strategies.
• Overcoming clinical translation challenges is crucial for realizing the full therapeutic benefits of exosomes.
• The integration of cold atmospheric plasma could unlock new avenues for effective exosome-based onco-therapeutics.