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Proliferative verrucus leukoplakia: A case series.
Mainak Datta1, Rupam Sinha1, Suman Sen1
1Department of Oral Medicine and Radiology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India.
Journal of Family Medicine and Primary Care
|September 19, 2022
Summary
Oral proliferative verrucous leukoplakia (OPVL) is a rare oral condition. Vitamin A supplementation shows promise as a potent treatment, aiding epithelialization and reducing recurrence in reported cases.
Area of Science:
- Oral pathology
- Dermatology
- Oncology
Background:
- Oral proliferative verrucous leukoplakia (OPVL) is a rare, progressive oral leukoplakia characterized by hyperkeratosis, multifocal disease, and exophytic features.
- OPVL presents without racial predilection but shows a female predominance, linked to factors like HPV, genetic susceptibility, and chronic trauma.
- Malignancy transformation rates for OPVL range from 0.13% to 17.5%, with a high propensity for recurrence.
Observation:
- This report details two cases of oral proliferative verrucous leukoplakia affecting the tongue and palate.
- Diagnosis was confirmed through comprehensive clinical and histopathological examinations.
- Treatment involved Vitamin A and its supplements.
Findings:
- Long-term follow-up of the two cases demonstrated no recurrence of the condition.
- Vitamin A treatment was associated with positive outcomes, suggesting its efficacy.
Implications:
- Vitamin A may be a potent therapeutic option for oral proliferative verrucous leukoplakia.
- Its antioxidant and epithelialization properties contribute to its effectiveness in managing OPVL.
- Further research into Vitamin A's role in OPVL treatment is warranted.
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