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Functional hyperthermia caused by obstructive sleep apnea syndrome: A case report
Hiroki Maita1, Tadashi Kobayashi2, Takashi Akimoto2
1Development of Community Healthcare, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Functional hyperthermia, a cause of unexplained fever, can be triggered by severe obstructive sleep apnea (OSA). Treating OSA with continuous positive airway pressure resolved the patient's fever and malaise.
Area of Science:
- Internal Medicine
- Sleep Medicine
Background:
- A 47-year-old male with diabetes, dyslipidemia, and hyperuricemia presented with a 3-month history of fever and malaise.
- Initial investigations, including blood tests and echocardiography, were unremarkable.
Observation:
- Whole-body CT revealed fatty liver, but non-alcoholic steatohepatitis was excluded.
- The patient reported snoring and weight gain, suggesting obstructive sleep apnea syndrome (OSAS).
Findings:
- Polysomnography confirmed severe obstructive sleep apnea syndrome (OSAS) with an apnea-hypopnea index of 44.5.
- Continuous positive airway pressure (CPAP) therapy was initiated.
Implications:
- CPAP treatment led to a gradual decrease in body temperature and resolution of malaise.
- This case highlights OSAS as a potential stressor for functional hyperthermia, responsive to CPAP intervention.
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