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Updated: Aug 28, 2025
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
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Night blood pressure variability, brain atrophy, and cognitive decline
Ji Hee Yu1, Regina E Y Kim2,3, So Young Park1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
Frontiers in Neurology
|September 19, 2022
Summary
High night blood pressure variability (BPV) is linked to brain volume reduction and cognitive decline. This finding suggests night BPV may predict accelerated brain aging in middle-aged adults.
Area of Science:
- Neurology
- Cardiology
- Gerontology
Background:
- Blood pressure variability (BPV) is an emerging risk factor for Alzheimer's disease.
- Limited research exists on the impact of nocturnal BPV on brain structure and cognition.
Purpose of the Study:
- To investigate the association between night BPV and brain atrophy.
- To examine the relationship between night BPV and cognitive function changes.
Main Methods:
- Analysis of 1,398 participants from the Korean Genome and Epidemiology Study.
- Utilized ambulatory blood pressure monitoring and 4-year follow-up brain MRI scans.
- Assessed cognitive function through a comprehensive neuropsychological test battery.
Main Results:
- Increased standard deviation (SD) of night systolic or diastolic BP correlated with reduced total brain volume.
- High SD of night systolic BP was linked to decreased gray matter volume, particularly in temporal regions (entorhinal cortex, fusiform gyrus).
- Elevated night systolic BPV was associated with declines in visual memory and verbal fluency.
Conclusions:
- Nocturnal BPV, not mean night BP, is associated with brain volume reduction and cognitive decline.
- High night BPV may serve as an independent predictor of accelerated brain aging in middle-aged populations.
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