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IL-10 rs1800896 Polymorphism: A Risk Factor for Adult Acute Lymphoblastic Leukemia
Ezeldine K Abdalhabib1, Badr Alzahrani1, Muhammad Saboor2,3,4
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.
Pharmacogenomics and Personalized Medicine
|September 19, 2022
Summary
Single-nucleotide polymorphism (SNP) in the interleukin-10 (IL-10) gene promoter, specifically rs1800896, is linked to an increased risk of adult acute lymphoblastic leukemia (ALL). This genetic variation elevates susceptibility to ALL regardless of patient demographics or leukemia subtype.
Area of Science:
- Genetics
- Oncology
- Immunology
Background:
- Single-nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene promoter can influence cancer development.
- The IL-10 gene plays a crucial role in immune regulation and has been implicated in various cancers.
Purpose of the Study:
- To investigate the genotypic frequency of the IL-10 rs1800896 polymorphism in adult patients with acute lymphoblastic leukemia (ALL).
- To determine if the IL-10 rs1800896 SNP is a risk factor for the development of adult ALL.
Main Methods:
- A case-control study involving 154 newly diagnosed adult ALL patients and 154 healthy controls.
- Genomic DNA was analyzed using allele-specific polymerase chain reaction (PCR) assays to genotype the rs1800896 polymorphism.
Main Results:
- The AG and AA genotypes of rs1800896 showed a significant association with adult ALL (p<0.001).
- The AG genotype of rs1800896 increased the risk for both B-cell and T-cell ALL (OR=2.51 and 4.70, respectively).
- No significant association was found between allelic frequencies and ALL, nor between the SNP and age, gender, or immunophenotype.
Conclusions:
- The rs1800896 polymorphism in the IL-10 gene promoter is associated with an increased risk of adult ALL.
- This genetic risk factor is independent of age at diagnosis, gender, and the specific immunophenotype of ALL.
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