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Predictors of Catching COVID-19 Infection during Pandemic Stage in Patients with Multiple Sclerosis (MS)

Mahsa Ghajarzadeh1,2, Omid Mirmosayyeb3, Negar Molazadeh1

  • 1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

International Journal of Preventive Medicine
|September 19, 2022
PubMed
Abstract

Insights

Patients with multiple sclerosis (MS) and cardiovascular disease face a higher risk of COVID-19 infection. Cardiovascular disease is a significant predictor, necessitating increased monitoring for these individuals.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Patients with multiple sclerosis (MS) are considered at increased risk for COVID-19 due to immunomodulatory and immunosuppressive treatments.
  • The specific risk factors for COVID-19 infection in MS patients remain unclear.
  • This study aimed to identify predictors of COVID-19 infection during the pandemic in individuals with MS.

Purpose of the Study:

  • To determine the predictors of COVID-19 infection in patients with multiple sclerosis.
  • To identify specific risk factors that increase susceptibility to SARS-CoV-2 in this population.

Main Methods:

  • A multicenter online screening study was conducted.
  • An online questionnaire collected self-reported demographic, MS-related, and COVID-19-related data from patients.
  • The questionnaire was disseminated via social media and WhatsApp, reaching 4160 MS patients.

Main Results:

  • 1448 MS patients participated; 1.7% (25) were diagnosed with COVID-19.
  • COVID-19 patients showed higher rates of rituximab treatment (28% vs 24%) and cardiovascular comorbidity (8% vs 1.6%).
  • Cardiovascular disease was identified as a significant positive predictor of COVID-19 infection (OR = 5.2).

Conclusions:

  • Patients with multiple sclerosis and coexisting cardiovascular disease are at a higher risk of COVID-19 infection.
  • Increased monitoring for COVID-19 is recommended for MS patients with cardiovascular conditions.
  • Identifying predictors aids in targeted public health strategies for vulnerable MS populations.
Keywords:
COVID-19Iranmultiple sclerosispredictor

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