Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff...

Area of Science:

• Coordination Chemistry
• Green Chemistry
• Materials Science

Background:

• Schiff bases are versatile ligands with diverse applications.
• Metal complexes offer tunable properties for various applications.
• Microwave irradiation provides a sustainable and efficient synthesis method.

Purpose of the Study:

• Synthesize and characterize novel Schiff base ligand and its transition metal complexes.
• Investigate the structural, thermal, and morphological properties of the synthesized compounds.
• Evaluate the antimicrobial and anticancer activities of the synthesized compounds.

Main Methods:

• Microwave-assisted synthesis of Schiff base ligand and metal complexes.
• Characterization using elemental analysis, spectroscopy (IR, UV-Vis, ESR), and magnetic susceptibility.
• Thermal analysis (TGA) and kinetic studies using Coats-Redfern and Horowitz-Metzger equations.
• Morphological analysis using Scanning Electron Microscopy (SEM) and particle size analysis.

Main Results:

• Successful synthesis of Schiff base ligand and Ni(II), Co(II), Zn(II), Cu(II), Mn(II), and Zr(IV) complexes.
• Structural elucidation confirmed via spectroscopic and magnetic data.
• Cu(II) complex exhibited notable cytotoxic activity against HepG-2 and HCT-116 cancer cell lines (IC50 = 18 and 22 μg/mL, respectively).

Conclusions:

• The green microwave approach is effective for synthesizing Schiff base metal complexes.
• The synthesized compounds possess interesting structural and thermal properties.
• The Cu(II) complex demonstrates promising anticancer potential, warranting further investigation.