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Factors Associated With In-Hospital Mortality in Mycosis Fungoides Patients: A Multivariable Analysis.

Amber Loren O King1, Victor Lee2, Fatima N Mirza3

  • 1Department of Dermatology, Yale School of Medicine, New Haven, USA.

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|September 19, 2022
PubMed
Summary

Mycosis fungoides (MF), a type of cutaneous T-cell lymphoma (CTCL), has associated in-hospital mortality linked to Sézary syndrome, sepsis, and older age. Researchers observed a decreasing mortality trend in MF patients over a decade.

Keywords:
ctclcutaneous t-cell lymphomamortalitymycosis fungoidesnedssepsissezary syndrome

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Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Mycosis fungoides (MF) is the predominant form of cutaneous T-cell lymphoma (CTCL).
  • While typically indolent, MF can evolve into aggressive CTCL subtypes.
  • Limited data exists on clinical factors predicting in-hospital mortality in MF patients.

Purpose of the Study:

  • To identify clinical factors associated with in-hospital mortality in mycosis fungoides patients.
  • To aid in developing risk-stratification and management strategies for hospitalized MF cases.

Main Methods:

  • Utilized the Nationwide Emergency Department Sample (NEDS) database for MF cases from 2006 to 2015.
  • Analyzed demographic and hospital characteristics stratified by survival outcomes.
  • Employed multivariable logistic regression to determine mortality predictors.

Main Results:

  • Identified 57,665 MF patients presenting to emergency departments (EDs) between 2006 and 2015.
  • Sézary syndrome, sepsis, and advanced age correlated with increased in-hospital mortality.
  • Female sex showed an inverse association with in-hospital mortality.
  • Observed a downward trend in in-hospital mortality for MF patients from 2006 to 2015.

Conclusions:

  • Identified key factors for risk-stratification in hospitalized mycosis fungoides patients.
  • Findings can inform targeted interventions and improve outcomes for high-risk individuals.