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Updated: Aug 28, 2025

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty
Brandon E Lung1, Taha M Taka2, Megan Donnelly1
1Orthopedic Surgery, University of California, Irvine, Irvine, USA.
Insights
Patients with a prior COVID-19 diagnosis undergoing elective total joint arthroplasty experienced higher blood loss but showed no increased risk of postoperative complications like VTE or infections. This suggests COVID-19 recovery does not negatively impact TJA outcomes.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Anesthesiology
Background:
- Coronavirus Disease-19 (COVID-19) can cause persistent symptoms, including respiratory issues, arrhythmias, and venous thromboembolism (VTE).
- With the resumption of elective total joint arthroplasties (TJA), the impact of a prior COVID-19 diagnosis on postoperative outcomes remains unclear.
Purpose of the Study:
- To investigate the implications of a prior resolved COVID-19 diagnosis on postoperative outcomes following elective TJA.
- To compare complication rates between TJA patients with and without a history of COVID-19.
Main Methods:
- Retrospective review of 155 elective TJA procedures performed in 2021.
- Patients were categorized based on a prior positive COVID-19 test result.
- Comparison of baseline demographics, time from COVID-19 diagnosis to surgery, preoperative colonization, laboratory markers, and various postoperative outcomes including VTE, infections, and length of stay.
Main Results:
- 24 out of 155 patients had a prior COVID-19 diagnosis, with a mean of 253 days between diagnosis and surgery.
- Patients with prior COVID-19 had significantly higher intraoperative estimated blood loss (EBL) (260 vs. 175 cc).
- No significant differences were observed in postoperative outcomes such as VTE, urinary tract infection, pneumonia, oxygen supplementation, cardiac arrhythmias, renal disease, sepsis, or periprosthetic joint infections up to six months post-surgery.
Conclusions:
- A prior COVID-19 diagnosis is associated with increased intraoperative blood loss during TJA but does not lead to significant differences in major postoperative complications.
- Asymptomatic patients with a history of COVID-19 undergoing elective TJA do not appear to require more aggressive prophylactic measures for VTE or infections.
- The findings suggest that a prior COVID-19 diagnosis has minimal impact on postoperative complications for elective TJA, supporting the resumption of these procedures.
Abstract:
Introduction Although a substantial portion of the United States population has been infected with and recovered from Coronavirus Disease-19 (COVID-19), many patients may have persistent symptoms and complications from disease-driven respiratory disease, arrhythmias, and venous thromboembolism (VTE). With institutions resuming elective total joint arthroplasties (TJA), it is unclear whether a prior resolved diagnosis of COVID has any implications on postoperative outcomes. Methods All elective TJA performed in 2021 at our institution were retrospectively reviewed and a history of prior COVID+ result recorded. Baseline demographics, days from prior COVID+ result to surgery date, preoperative methicillin-resistant Staphylococcus aureus (MRSA) nares colonization, and laboratory markers were obtained to determine baseline characteristics. Postoperative estimated blood loss (EBL), length of stay (LOS), rate of revision surgery, and discharge destination were compared between groups. Perioperative and postoperative rates of VTE, urinary tract infection (UTI), pneumonia, postoperative oxygen supplementation, cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery were recorded. Results Of the 155 elective TJA performed in 2021, 24 patients had a prior COVID+ diagnosis with a mean of 253 days from positive result to surgery date. There were no significant differences in baseline demographics, comorbidities, and preoperative lab markers between groups. Surgeries on patients with a prior COVID+ had a significantly higher EBL (260 vs 175cc), but postoperative outcomes of VTE, UTI, pneumonia, oxygen supplementation requirement, nares MRSA+, cardiac disease, and infection rates between groups were similar. Bivariate logistic regression revealed increased days from COVID+ diagnosis (>6 months) to surgery date were associated with a shorter LOS. Conclusion Although a prior COVID+ diagnosis had increased intraoperative blood loss, there were no significant differences in respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA. This study suggests that asymptomatic C+ patients receiving elective TJA do not require more aggressive prophylactic anticoagulation or antibiotic regimens to prevent VTE or perioperative infections. As institutions around the nation resume pre-COVID rates of arthroplasty surgeries, a prior diagnosis of COVID appears to have no effects on postoperative complications.
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