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A study of the top-cited studies on drug therapy for HIV
Jie Tang1, Yanwen Yuan1, Lei Sun2
1Editorial Board of Journal of Sichuan University (Medical Science Edition), Sichuan University, Chengdu, China.
Insights
Bibliometric analysis of the top 100 cited studies on human immunodeficiency virus (HIV) drug therapy reveals key research trends. Most influential HIV drug research focuses on adverse events, basic science, and adherence.
Area of Science:
- Bibliometrics
- Medical Research
- Pharmacology
Background:
- Human immunodeficiency virus (HIV) drug therapy research is a significant area, but comprehensive data analysis is lacking.
- Bibliometric methods can effectively assess the status and trends of highly cited studies in HIV drug therapy.
Purpose of the Study:
- To evaluate the status and trends of the most cited studies on human immunodeficiency virus (HIV) drug therapy.
- To identify influential research areas and contributions in HIV drug treatment.
Main Methods:
- Bibliometric analysis using the Web of Science Core Collection database.
- Selection of the top 100 most cited studies on HIV drug therapy published up to July 26, 2022.
- Data analysis and visualization using VOSviewer software.
Main Results:
- The 100 top-cited studies, published between 1987 and 2017, received 451 to 5597 citations.
- Key journals include New England Journal of Medicine, Lancet, and JAMA; the United States, Switzerland, and England were leading contributors.
- Research hotspots identified include clinical trials, treatment adverse events, basic research, and clinical adherence.
Conclusions:
- The most impactful HIV drug therapy research is predominantly published in the United States.
- Key areas of focus for highly cited studies are treatment adverse events, basic research, and clinical adherence.
- This analysis provides a foundational list of influential academic contributions for researchers in HIV drug treatment.
Abstract:
Background Research on drug therapy for HIV remained major hot-spots, but relevant data were not satisfactory. We aimed to assess the status and trends of the most cited studies on drug therapy for HIV by using bibliometric methods. Methods The Web of Science Core Collection database was searched for the drug therapy for HIV studies. The period for retrieval was from the beginning of the database to July 26, 2022. The 100 top cited studies were selected. These general information and bibliometric data were collected and analyzed. VOS viewer software was used for visualization analysis. Results The number of citations for the 100 top cited studies ranged from 451 to 5597 and were published from 1987 to 2017. These studies were published in 29 journals. The top 3 journals in terms of the number of studies were the New England Journal of Medicine (n = 22), Lancet (n = 15), and JAMA (n = 13). The most frequently nominated author was Matthias Eiger from the University of Bern, who has contributed 5 studies. United States, Switzerland, and England contributed most of the highly cited studies. Research hot spots reflected clinical trials, treatment adverse events, basic research, and clinical adherence. Conclusion The majority of 100 top-cited studies have been published in the United States, and primarily focused on treatment adverse events, basic research, and clinical adherence. They provide a basic list of the most important and influential academic contributions to literature of HIV drug treatment for researchers.
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