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A carpipramine related fatality.

A D Fraser, A F Isner

    Journal of Forensic Sciences
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    This case report details the first known fatality involving carpipramine, a tricyclic antidepressant, combined with ethyl alcohol. Quantitative analysis confirmed significant levels of both substances in biological samples.

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    Area of Science:

    • Forensic Toxicology
    • Clinical Pharmacology

    Background:

    • Tricyclic antidepressants (TCAs) are widely prescribed for various psychiatric conditions.
    • Carpipramine, a TCA, has a known side effect profile, but fatalities are rare.
    • The interaction between TCAs and alcohol can potentiate adverse effects.

    Observation:

    • A fatality occurred following the ingestion of carpipramine (Prazinil) and ethyl alcohol.
    • Postmortem analysis revealed carpipramine concentrations of 2.0 mg/L in blood and 0.44 mg/L in urine.
    • Ethyl alcohol was detected at 105 mg/dL in blood and 55 mg/dL in urine.

    Findings:

    • High-performance liquid chromatography (HPLC) was used to quantitate carpipramine.
    • Headspace gas chromatography confirmed ethyl alcohol levels.

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  • Thin-layer chromatography (TLC) identified carpipramine in stomach contents.

    • Implications:

    • This case represents the first documented fatality involving carpipramine.
    • Highlights the potential risks of combining carpipramine with alcohol.
    • Underscores the importance of quantitative toxicological analysis in postmortem investigations.