Numerical investigation of arterial stenosis location affecting hemodynamics considering microcirculation function

Area of Science:

• Biomedical Engineering
• Fluid Dynamics
• Medical Physics

Background:

• Arterial stenosis is a significant health concern.
• Understanding its hemodynamic effects is critical for patient outcomes.

Purpose of the Study:

• To investigate hemodynamic parameter changes in various arterial stenosis locations.
• To analyze the influence of stenosis position on blood flow and pressure.

Main Methods:

• Utilized a numerical simulation approach.
• Employed the finite element method (FEM) for analysis.
• Incorporated fluid-structure interaction and microcirculation boundary conditions.

Main Results:

• Hemodynamic parameters are highly sensitive to stenosis location.
• Stenosis nearer to microcirculation leads to decreased blood flow velocity, pressure, and wall shear stress.
• Observed a velocity profile shift with changing stenosis proximity to the microcirculation zone.

Conclusions:

• Stenosis location critically affects arterial hemodynamics, particularly concerning microcirculation.
• Microcirculation plays a vital role in numerical simulations of arterial blood flow.
• Findings offer potential clinical insights for diagnosing and treating arterial stenosis.