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Updated: Aug 28, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes

Dieter Petit1,2, Manuel Hitzenberger3, Matthias Koch1,2

  • 1VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.

The EMBO Journal
|September 19, 2022
PubMed

Keywords:
Alzheimer's diseaseamyloid precursor proteinamyloid βpreselininγ-secretaseγ-secretase modulators

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