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Updated: Aug 28, 2025
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Return to work in patients with head and neck cancer: Systematic review and meta-analysis
Justin Yu1,2, Justin Smith1,3, Ravi Marwah1,3
1Townsville University Hospital, Townsville, Queensland, Australia.
Background:
The aim of this review was to determine the prevalence of return to work (RTW) amongst head and neck cancer (HNC) survivors and to determine its impact on quality of life (QoL).
Methods:
A literature search was conducted in PubMed, Scopus, Embase and CINAHL in March 2021. Articles were included if they reported the number of patients with HNC receiving definitive treatment who were working at the time of diagnosis and returned to work.
Results:
There were 21 articles deemed eligible for inclusion. Meta-analysis suggested that 67% of patients with HNC who were employed at diagnosis RTW (95% CI 62%-73%, I2 = 97.53%). Patients who RTW were demonstrated to have lower levels of anxiety and depressive symptoms on the Hospital Anxiety and Depression Scale.
Conclusions:
Return to work is an important clinical outcome which must be considered in the survivorship care of patients with HNC.
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