Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
Types of RNA01:20

Types of RNA

6.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
6.1K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

216
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
216
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.9K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.9K
Experimental RNAi02:15

Experimental RNAi

6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Mobilization with Mechanical Axis Preservation: A Prospective Outcome Analysis of Titanium Elastic Nailing in Femoral Shaft Fractures of School-Aged Children.

Journal of orthopaedic case reports·2026
Same author

Microbial proteases and endothelial barrier disruption in sepsis: A neglected nexus.

Virulence·2026
Same author

Immunomodulator drugs: Mechanism of action and systemic effects.

Advances in protein chemistry and structural biology·2026
Same author

Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem Cell Dynamics.

Molecular neurobiology·2026
Same author

The gut microbiome axis: how Lactobacillus-fermented soymilk orchestrates health.

Archives of microbiology·2026
Same author

Timing of transfer to a tertiary care center and early surgical outcome of obstructed total anomalous pulmonary venous connection in resource-limited settings.

Annals of pediatric cardiology·2026

Related Experiment Video

Updated: Aug 28, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

565

Long Non-coding RNA Therapeutics: Recent Advances and Challenges.

Anjali Sangeeth1, Mahesh Malleswarapu1, Amit Mishra2

  • 1Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad 500046 (TS), India.

Current Drug Targets
|September 19, 2022
PubMed
Summary

Non-coding RNAs, like microRNAs (miRNAs) and long noncoding RNAs (LncRNAs), are crucial regulators in biology. RNA-based therapeutics targeting these molecules offer new avenues for treating diseases and advancing personalized medicine.

Keywords:
AMLCMLcircRNAslncRNAsmiRNAsribozyme

More Related Videos

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.5K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

8.9K

Related Experiment Videos

Last Updated: Aug 28, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

565
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.5K
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

8.9K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • RNA's role extends beyond mRNA, encompassing catalytic (ribozyme) and regulatory functions.
  • Non-coding RNAs, particularly microRNAs (miRNAs) and long non-coding RNAs (LncRNAs), are increasingly recognized as key biological regulators.
  • Recent research highlights diverse non-coding RNAs and their cellular mechanisms.

Purpose of the Study:

  • To review recent advancements and challenges in the field of non-coding RNA research.
  • To explore RNA-based therapeutics targeting miRNAs and LncRNAs for disease treatment.
  • To summarize the current status of RNA-based therapeutics in clinical trials and FDA approval.

Main Methods:

  • Literature review of recent studies on non-coding RNAs.
  • Analysis of RNA's regulatory roles in biological processes.
  • Overview of RNA-based drug platforms and therapeutic strategies.

Main Results:

  • Non-coding RNAs are vital regulators across numerous biological pathways.
  • LncRNA-targeted drug platforms present significant pharmaceutical opportunities, modulating diseases genetically.
  • RNA therapeutics show potential in overcoming protein-related limitations and advancing personalized medicine.

Conclusions:

  • RNA-based therapeutics hold promise for transforming healthcare across various diseases.
  • The field is rapidly evolving, with ongoing clinical trials and FDA-approved treatments.
  • Targeting non-coding RNAs represents a frontier in developing effective and personalized medical interventions.