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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Aug 28, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Manganese-Based Tumor Immunotherapy.

Ke Zhang¹, Chao Qi¹, Kaiyong Cai¹

¹Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.

Advanced Materials (Deerfield Beach, Fla.)

|September 19, 2022

Summary

This summary is machine-generated.

Manganese (Mn)-based nanoparticles show promise in cancer immunotherapy by delivering drugs, enhancing immune responses, and enabling imaging. This review highlights their potential in nanomedicine for improved tumor treatment strategies.

Keywords:

cGAS-STING immunotherapy manganese-based nanoplatforms synergistic treatments theranostics

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Area of Science:

Biomedical Engineering
Nanomedicine
Immunology

Background:

Manganese (Mn) is an essential micronutrient vital for immune function, hematopoiesis, and oxidative stress regulation.
Mn-based nanoparticles offer biocompatibility and diverse applications in nanomedicine, particularly for cancer immunotherapy.

Purpose of the Study:

To review recent advancements in Mn-based nanoplatforms for tumor immunotherapy.
To discuss the characteristics of Mn guiding nanoplatform design.
To explore biomedical applications including immunotherapy, multimodal therapy, and imaging-guided approaches.

Main Methods:

Literature review focusing on recent progress in Mn-based nanoplatforms for tumor immunotherapy.
Discussion of Mn characteristics relevant to nanoplatform design.
Analysis of applications in single-agent immunotherapy, synergistic therapies, and imaging-guided treatments.

Main Results:

Mn-based nanoplatforms can act as carriers for immunotherapeutic agents.
They function as adjuvants to modulate the tumor immune microenvironment.
Mn nanoparticles can activate the host immune system via the cGAS-STING pathway.
Manganese ions (Mn2+) serve as effective contrast agents for real-time MRI monitoring of immunotherapy efficacy.

Conclusions:

Mn-based nanoplatforms present multifaceted strategies for enhancing tumor immunotherapy.
Further development is needed to address challenges and optimize their clinical translation.
Multifunctional Mn nanoplatforms hold significant potential for future cancer treatment paradigms.