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Primary hyperparathyroidism and chronic lymphocytic leukemia.

J C Wang, W Steier, M K Aung

    Cancer
    |October 1, 1978
    PubMed
    Summary

    Hypercalcemia is rare in chronic lymphocytic leukemia (CLL). This study found parathyroid adenomas in three of thirteen reported CLL hypercalcemia cases, suggesting surgical consideration for this treatable cause.

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    Area of Science:

    • Oncology
    • Endocrinology
    • Hematology

    Background:

    • Hypercalcemia is a common complication in many cancers.
    • Its occurrence in chronic lymphocytic leukemia (CLL) is exceptionally rare, with only eleven prior case reports.
    • The underlying mechanisms for hypercalcemia in CLL patients are often not well-understood.

    Observation:

    • This report details two additional cases of chronic lymphocytic leukemia (CLL) presenting with hypercalcemia.
    • In both cases, a parathyroid adenoma was identified as the cause.
    • One patient, diagnosed ante mortem, showed significant improvement following parathyroidectomy.

    Findings:

    • A review of thirteen reported cases of CLL with hypercalcemia revealed that three were associated with parathyroid adenomas.
    • Osteoclast activating factor levels were normal in one patient.
    • Parathyroid adenoma was identified in both new cases.

    Implications:

    • The findings suggest that parathyroid adenoma should be considered in the differential diagnosis of hypercalcemia in patients with chronic lymphocytic leukemia (CLL).
    • Early identification and surgical intervention (parathyroidectomy) can lead to effective treatment and improved outcomes.
    • Further investigation into the association between CLL and parathyroid disease may be warranted.

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