At-home Bleaching with a Novel Carbamide Peroxide Polymeric Nanoparticle Gel: A Multicenter Randomized Controlled...

Area of Science:

• Dental Aesthetics
• Materials Science in Dentistry

Background:

• Tooth sensitivity (TS) is a common concern with at-home bleaching treatments.
• Carbamide peroxide is a widely used agent for dental bleaching.
• Novel formulations aim to improve efficacy and reduce side effects like TS.

Purpose of the Study:

• To compare the efficacy and tooth sensitivity of a novel polymeric nanoparticle carbamide peroxide gel versus a commercial carbamide peroxide gel.
• To evaluate the impact of two application times (30 and 60 minutes) on bleaching effectiveness and TS.

Main Methods:

• A multicenter, triple-blind, split-mouth randomized controlled trial involving 80 adults.
• Participants used experimental and control gels for 30 or 60 minutes daily for four weeks.
• Tooth sensitivity was assessed using Numeric Rating Scale and Visual Analogue Scale; color change was measured using shade guide units and spectrophotometry.

Main Results:

• No statistically significant differences were found in the risk or intensity of tooth sensitivity between the novel and commercial gels.
• Both bleaching gels, regardless of application time, demonstrated comparable color change efficacy 30 days post-treatment.
• No significant differences in color change were observed based on the gel type or application duration.

Conclusions:

• The novel polymeric nanoparticle carbamide peroxide gel is as effective as the commercial gel in terms of color change.
• The novel gel formulation results in a low rate of tooth sensitivity, comparable to the commercial product.
• Application times of 30 or 60 minutes per day are both effective for at-home bleaching with this novel gel.