Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality Assessment in Paediatric Cardiology: Experiences from Leveraging a Clinical Data Warehouse.

Life (Basel, Switzerland)·2026
Same author

Assessing the contribution of rare variants to congenital heart disease through a large-scale case-control exome study.

NPJ genomic medicine·2026
Same author

Cardiopulmonary Exercise Testing Combined With Stress Echocardiography for the Evaluation of Myocardial Dysfunction in Patients at Risk for Coronary Insufficiency.

Pediatric exercise science·2026
Same author

Neurodevelopment and psychosocial adjustment in children with early surgical ventricular septal defect repair: exploring the influence of surgery-related variables across childhood and adolescence.

Journal of cardiothoracic surgery·2026
Same author

Fontan associated protein-losing enteropathy is linked to distinct metabolic and hepatic alterations.

Scientific reports·2026
Same author

NK cell-mediated tumor cell killing by bispecific innate cell engagers induces ADCC-mediated activation of primary human dendritic cells.

Oncoimmunology·2026

Related Experiment Video

Updated: Aug 28, 2025

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.0K

Microplegia in paediatric hearts.

Frank Münch1, Nicola Kwapil1, Andreas Teske1

  • 1Department of Paediatric Cardiac Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany.

Perfusion
|September 19, 2022
PubMed
Summary

Paediatric microplegia offers safe myocardial protection for infant hearts without haemodilution. This novel concentration-dependent approach requires adapted surgical management for optimal outcomes in pediatric cardiac surgery.

Keywords:
cardio-pulmonary-bypasscardioplegiainfantsischaemiamicroplegia

More Related Videos

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

858
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.3K

Related Experiment Videos

Last Updated: Aug 28, 2025

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.0K
Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

858
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.3K

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Biomedical Engineering

Background:

  • Optimal myocardial protection is crucial for successful heart surgery outcomes.
  • Standard cardioplegia strategies for adults are not suitable for infant hearts.
  • Paediatric microplegia provides myocardial protection without haemodilution, adapting adult techniques for pediatric use.

Purpose of the Study:

  • To introduce and describe the clinical implementation of a novel concentration-dependent paediatric microplegia technique.
  • To highlight the advantages of paediatric microplegia in terms of myocardial protection and avoiding haemodilution in infant cardiac surgery.

Main Methods:

  • Paediatric microplegia administered via a roller pump using a specific mixture of potassium (K) and magnesium (Mg) as cardioplegic additives.
  • The additive is mixed with arterial blood from the oxygenator in flow-dependent ratios.
  • Initial application involves 25 mmol/L K and 11 mmol/L Mg for 2 minutes, with subsequent reduced doses every 20 minutes for prolonged aortic clamping.

Main Results:

  • Achieved safe cardioplegic cardiac arrest with immediate return to spontaneous rhythm upon reperfusion.
  • Demonstrated successful myocardial protection without haemodilution.
  • Highlighted the technical simplicity for perfusionists.

Conclusions:

  • Paediatric microplegia is a safe and effective myocardial protection strategy for infant heart surgery.
  • The technique avoids haemodilution and is technically straightforward for perfusionists.
  • Requires adapted intraoperative management from surgeons due to the 20-minute interval for microplegia application.