Progressive supranuclear palsy with lower motor neuron involvement. A case report.

Area of Science:

• Neurology
• Neuroscience
• Clinical Medicine

Background:

• Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease.
• Typical PSP symptoms include supranuclear ophthalmoplegia, pseudobulbar palsy, axial dystonia, parkinsonism, postural instability, and dementia.

Observation:

• This report details a unique case of PSP.
• The patient exhibited flexor dystonia of the neck, an atypical presentation.
• Significant lower motor neuron involvement was also noted.

Findings:

• The case challenges the classically described clinical phenotype of PSP.
• The presence of flexor dystonia and lower motor neuron signs suggests potential variations or subtypes of PSP.
• This presentation expands the known spectrum of PSP clinical manifestations.

Implications:

• Further research is needed to understand the variability in PSP presentations.
• This case may inform diagnostic criteria and differential diagnoses for atypical parkinsonian syndromes.
• Understanding these variations can improve patient management and therapeutic strategies for progressive supranuclear palsy.