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Use of low molecular weight heparin and hemoglobin fall in COVID-19 patients: A STROBE-compliant study

Ping-Yang Hong1, Mao-Hong Huang, An-Ke Hu

  • 1Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University; the Third Clinical College of Fujian Medical University, Fujian, China.

Medicine
|September 20, 2022
PubMed

Insights

Low molecular weight heparin (LMWH) did not significantly lower hemoglobin levels in COVID-19 pneumonia patients. This study found no adverse effect of LMWH on hemoglobin fall, even in nonsevere cases.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pharmacology

Background:

  • Anticoagulation with low molecular weight heparin (LMWH) is considered for COVID-19 patients.
  • Potential adverse effects of LMWH, particularly on hemoglobin levels, require further investigation.

Purpose of the Study:

  • To assess the impact of LMWH on hemoglobin decline in patients with COVID-19 pneumonia.
  • To determine if LMWH use is associated with adverse effects on red blood cell mass.

Main Methods:

  • Retrospective analysis of electronic medical records from 179 COVID-19 pneumonia patients.
  • Patients were categorized into LMWH and control groups.
  • Statistical analyses included Mann-Whitney U test, Spearman correlation, and logistic regression to evaluate hemoglobin changes and confounding factors.

Main Results:

  • The LMWH group showed a greater median hemoglobin decrease (-6.0 g/L) compared to the control group (-2.0 g/L) (P < .001).
  • Multivariate regression analysis, after adjusting for confounders, revealed no significant association between LMWH use and hemoglobin decrease (P > .05).
  • Preventive LMWH use did not lower hemoglobin in nonsevere COVID-19 pneumonia patients.

Conclusions:

  • In COVID-19 pneumonia patients, LMWH treatment was not found to be an independent risk factor for significant hemoglobin reduction.
  • The findings suggest that LMWH can be safely used in this patient population without concerning adverse effects on hemoglobin levels.

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