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An Experimental Protocol for Femtosecond NIR/UV - XUV Pump-Probe Experiments with Free-Electron Lasers

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Published on: October 23, 2018

Picosecond infrared laser driven sample delivery for simultaneous liquid-phase and gas-phase electron diffraction

Zhipeng Huang¹, Meghanad Kayanattil¹, Stuart A Hayes¹

¹Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761 Hamburg, Germany.

Structural Dynamics (Melville, N.Y.)

|September 20, 2022

Summary

A new laser-based method delivers nanoscale liquid droplets and gas-phase samples for ultrafast electron diffraction. This technique enables real-time observation of both gas and solution phase dynamics with minimal sample use.

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$Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing$

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Published on: April 25, 2019

Area of Science:

Physical Chemistry
Materials Science
Biophysics

Background:

Femtosecond electron diffraction (FED) requires precise sample delivery for studying ultrafast dynamics.
Existing methods face challenges in delivering intact biomolecules or probing solution-phase dynamics.

Purpose of the Study:

To develop a novel laser-driven molecular beam technique for simultaneous gas-phase and nanoscale liquid droplet delivery.
To enable time-resolved studies of both gas and solution phase dynamics using FED.

Main Methods:

Utilizing Picosecond InfraRed Laser (PIRL) excitation to induce Desorption by Impulsive Vibrational Excitation (DIVE).
Employing glycerol as a model system, with selective excitation of the OH stretch region.
Simultaneous imaging of the generated plume using an ultrafast electron gun and optical microscope.

Main Results:

The PIRL-DIVE method successfully generated both gas-phase and nanoscale liquid droplets.
Plume characterization revealed distinct gas and liquid phases depending on excitation conditions.
Continuous probing from gas to solution phase dynamics was achieved with high efficiency and low sample consumption (<100 nl per image).

Conclusions:

The PIRL-DIVE technique offers a versatile approach for sample delivery in FED studies.
It facilitates the study of intact biomolecules and solution-phase chemistry with atomic resolution.
This method allows for the separation of solvent effects in molecular dynamics.