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Formulating and Characterizing an Exosome-based Dopamine Carrier System
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Ethosomes: A novel drug carrier.

Neha Chauhan1, Parul Vasava1, Sharuk L Khan2

  • 1Laxminarayan Dev College of Pharmacy, Gujarat Technological University, Bharuch, Gujarat, India.

Annals of Medicine and Surgery (2012)
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Ethosomes, lipid nanocarriers with ethanol, enhance transdermal drug delivery. This review explores ethosome generations and compares them to liposomes for improved skin penetration.

Keywords:
ApplicationsEthosomesProteins and peptides deliveryTransdermal delivery

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Area of Science:

  • Nanotechnology
  • Pharmaceutics
  • Dermal Drug Delivery

Background:

  • Ethosomes are advanced lipid vesicular carriers developed over two decades ago.
  • They incorporate a significant amount of ethanol, enhancing their skin penetration capabilities.
  • Ethosomes are effective nanocarriers for diverse medicinal substances, facilitating deep skin layer delivery.

Purpose of the Study:

  • To review the evolution of ethosomal systems across different generations.
  • To compare the efficacy of ethosomes with conventional liposomes in transdermal drug delivery.
  • To highlight novel preparation methods and formulations of ethosomes.

Main Methods:

  • Review of scientific literature on ethosomal systems since their inception in 1996.
  • Analysis of studies involving various ethosome compositions and formulations (gels, patches, lotions).
  • Examination of in vivo models and clinical trials assessing dermal/transdermal administration effectiveness.

Main Results:

  • Ethosomes demonstrate significant advancements in transdermal drug delivery over 20 years.
  • Variations in ethosome composition have led to enhanced drug carrying and skin permeation properties.
  • Ethosomes show potential for improved delivery compared to traditional liposomes.

Conclusions:

  • Ethosomes represent a significant progression in nanocarrier technology for transdermal applications.
  • Ongoing research continues to refine ethosome formulations and delivery strategies.
  • Ethosomes offer a promising alternative for enhancing the efficacy of dermal and transdermal drug delivery systems.