Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

235
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
235
Oogenesis02:07

Oogenesis

64.0K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
64.0K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

625
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
625
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

949
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
949
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

2.3K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
2.3K
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

1.7K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gynaecomastia secondary to transdermal oestradiol used for androgen deprivation therapy: informed reality vs subjective fear.

BJU international·2026
Same author

Recent Advancements in the Development of Heterocyclic Scaffolds as Potential Anti-cancer Agents Targeting EGFR and VEGFR-2.

Mini reviews in medicinal chemistry·2026
Same author

Establishment of two Hypotheses for Gut Bacterial Alteration Process for Minimizing the Intestinal Communicable Diseases.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2026
Same author

Hybridization of isatin and benzoxazolinone via a diethyl spacer: a new scaffold for breast cancer drug discovery.

Future medicinal chemistry·2026
Same author

How Cancer Online Support Groups Work, for Whom, and in What Circumstances: Realist Review.

Journal of medical Internet research·2026
Same author

Experimental and computational analysis of SERCA inhibition by naphthoquinone derivatives.

Bioorganic & medicinal chemistry·2026

Related Experiment Video

Updated: Aug 28, 2025

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids
07:37

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

1.5K

Serum estradiol levels decrease after oophorectomy in transmasculine individuals on testosterone therapy.

Sahil Kumar1,2, Elise Bertin2, Cormac O'Dwyer1,2

  • 1Faculty of Medicine, University of British Columbia, Vancouver V6T 1Z4, British Columbia, Canada.

Asian Journal of Andrology
|September 20, 2022
PubMed
Summary

Oophorectomy in transmasculine individuals on testosterone therapy significantly reduces estradiol levels. This surgical option further lowers estradiol compared to testosterone therapy alone, with limited data on broader health outcomes.

Keywords:
estradiolgender-affirming surgeryhysterectomyoophorectomytestosterone therapytransmasculine

More Related Videos

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.9K
Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
09:36

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

10.1K

Related Experiment Videos

Last Updated: Aug 28, 2025

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids
07:37

Author Spotlight: Advancing Human Ovarian Repair and Cancer Studies with Surface Epithelium Organoids

Published on: August 16, 2024

1.5K
Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.9K
Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production
09:36

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Published on: November 17, 2023

10.1K

Area of Science:

  • Endocrinology
  • Transgender Health
  • Surgical Outcomes

Background:

  • Transmasculine individuals may opt for hysterectomy with salpingectomy and consider oophorectomy.
  • Limited data exist on health outcomes related to ovarian retention versus removal in this population.
  • Previous studies on testosterone therapy often excluded patients who underwent oophorectomy.

Purpose of the Study:

  • To evaluate the impact of oophorectomy on estradiol levels in transmasculine individuals on high-dose testosterone therapy.
  • To compare estradiol and testosterone levels in patients who underwent oophorectomy versus those who retained their ovaries.

Main Methods:

  • Retrospective chart review of transmasculine patients at an endocrine clinic.
  • Included 12 patients who underwent bilateral oophorectomy (cases) and 12 matched controls who did not.
  • Collected and compared presurgical and postsurgical serum hormone data.

Main Results:

  • Oophorectomy led to a statistically significant decrease in estradiol levels post-surgery compared to pre-surgery levels (P = 0.02).
  • Follow-up estradiol levels were significantly lower in the oophorectomy group compared to the control group (P = 0.03).
  • No significant differences in total testosterone levels were observed between groups at baseline or follow-up.

Conclusions:

  • Oophorectomy in transmasculine individuals on high-dose testosterone therapy further suppresses estradiol levels.
  • The clinical implications of oophorectomy versus ovarian retention require further investigation, particularly regarding bone health and overall endocrinological outcomes.