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Two Important Players for Type 2 Diabetes Mellitus: Metrnl and Asprosin

Mustafa Timurkaan, Esra S Timurkaan

    Clinical Laboratory
    |September 20, 2022
    PubMed
    Abstract

    Insights

    New research reveals that higher asprosin and lower Metrnl levels are linked to type 2 diabetes (T2DM) and insulin resistance. These adipomyokines may serve as early indicators for T2DM development.

    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Biochemistry

    Background:

    • Diabetes mellitus (DM) prevalence is rising globally.
    • Metrnl and asprosin are novel adipomyokines influencing glucose tolerance and insulin resistance.
    • Understanding their role in type 2 diabetes (T2DM) is crucial.

    Purpose of the Study:

    • To investigate the relationship between T2DM, serum Metrnl and asprosin levels, and insulin resistance.
    • To compare Metrnl and asprosin levels in newly diagnosed T2DM patients versus healthy controls.

    Main Methods:

    • A cohort of 60 treatment-naive T2DM patients and 60 healthy controls were enrolled.
    • Serum levels of Metrnl and asprosin were measured.
    • Insulin resistance was assessed using HOMA-IR, alongside measurements of insulin, BMI, triglyceride, and glucose levels.

    Main Results:

    • Serum Metrnl levels were significantly lower in T2DM patients compared to controls (p < 0.01).
    • Serum asprosin levels were significantly higher in T2DM patients compared to controls (p < 0.01).
    • Asprosin positively correlated with HOMA-IR, insulin, BMI, and triglycerides, while Metrnl negatively correlated with HOMA-IR, insulin, triglycerides, and glucose.

    Conclusions:

    • This study is the first to compare Metrnl and asprosin in relation to T2DM and HOMA-IR in humans.
    • Elevated asprosin and reduced Metrnl levels are associated with T2DM.
    • Metrnl and asprosin show potential as early biomarkers for insulin resistance in T2DM.

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