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Laboratory testing and antihypertensive medication adherence following initial treatment of incident, uncomplicated

Reed F Beall1, Alexander A Leung1,2, Amity E Quinn2

  • 1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Journal of Clinical Hypertension (Greenwich, Conn.)
|September 20, 2022
PubMed

Insights

Medication adherence for new hypertension patients is poor, with over half non-persistent within six months. Frequent laboratory testing and follow-up significantly improve persistence with antihypertensive therapy.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Medication adherence is crucial for managing hypertension and preventing complications.
  • Understanding factors influencing adherence is vital for improving patient outcomes.
  • Antihypertensive therapy persistence is often suboptimal in newly diagnosed patients.

Purpose of the Study:

  • To investigate the association between baseline laboratory assessment and/or follow-up with persistence in antihypertensive therapy among newly diagnosed hypertension patients.
  • To determine the frequency of laboratory testing in this patient cohort.
  • To compare medication persistence rates based on patient, neighborhood, and treatment factors.

Main Methods:

  • Retrospective cohort study utilizing administrative and laboratory data from April 1, 2012, to March 31, 2017, in Alberta, Canada.
  • Inclusion of 103,232 newly diagnosed, uncomplicated hypertension patients who filled their first antihypertensive prescription.
  • Analysis of medication persistence within six months, examining associations with laboratory testing frequency and other patient/neighborhood factors.

Main Results:

  • Over half (52.5%) of patients were non-persistent with antihypertensive medication within six months.
  • Higher medication persistence was observed in females and those residing in higher social status neighborhoods (excluding rural areas).
  • The strongest predictor of persistence, besides older age, was the performance of hypertension-related laboratory testing, with increased frequency correlating with higher persistence.

Conclusions:

  • Medication persistence in newly diagnosed hypertension is suboptimal, posing a significant barrier to treatment benefits.
  • Regular patient follow-up, including laboratory testing, appears critical for enhancing long-term adherence to antihypertensive therapy.
  • Further research into interventions promoting consistent medication use is warranted.

Keywords:
adherencegender differenceshypertension-generalprimary care issues

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