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Idiopathic Hirsutism and Metabolic Status: A Population-based Prospective Cohort Study
Leila Mahmoudieh1, Mina Amiri1, Maryam Rahmati1
1Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The Journal of Clinical Endocrinology and Metabolism
|September 20, 2022
Summary
Idiopathic hirsutism (IH) in women does not significantly impact long-term cardiometabolic health, including diabetes and hypertension risks. Routine screening for these conditions in women with IH is not recommended based on current findings.
Area of Science:
- Endocrinology
- Metabolic Health
- Women's Health
Background:
- Idiopathic hirsutism (IH) has shown inconsistent associations with cardiometabolic parameters in prior research.
- This study addresses the need for clearer understanding of IH's impact on metabolic health outcomes.
Purpose of the Study:
- To investigate the longitudinal effect of idiopathic hirsutism (IH) on various metabolic and cardiometabolic risk factors in women.
- To compare the development of metabolic disorders in women with IH versus healthy controls over time.
Main Methods:
- A population-based prospective study involving 334 women with IH and 1226 healthy controls from the Tehran Lipid and Glucose Study.
- Longitudinal trends of metabolic indices (fasting blood sugar, lipids, blood pressure, waist circumference) were analyzed using generalized estimation equations.
- Cox regression models assessed the hazard ratios for metabolic disorders, adjusting for confounding factors.
Main Results:
- Women with IH exhibited higher levels of total testosterone, free androgen index, androstenedione, and dehydroepiandrosterone sulfate compared to controls.
- No significant long-term differences were observed in mean changes of key metabolic indices (FBS, HDL-C, LDL-C, non-HDL-C, TG, SBP, DBP, WC) between groups.
- While unadjusted analysis showed a marginally significant association with type 2 diabetes mellitus (T2DM), this disappeared after adjusting for confounders; no significant differences in the hazard of hypertension or metabolic syndrome were found.
Conclusions:
- Idiopathic hirsutism (IH) is not associated with significant long-term adverse changes in metabolic risk factors or cardiometabolic outcomes.
- The study does not support routine screening for metabolic disorders in women diagnosed with IH.
- Findings highlight the importance of considering confounders in the association between IH and metabolic health.
Keywords:
Tehran lipid and glucose study (TLGS)diabetes mellitus (T2DM)hypertension (HTN)idiopathic hirsutism (IH)metabolicmetabolic syndrome (MetS)More Related Videos
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