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Brain Related Gut Peptides - A Review
Nivedita Manoharan1, Dheepthi Jayamurali1, Rajeshwari Parasuraman1
1Department of Physiology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, The University of Madras, Taramani, Chennai-600113, India.
Protein and Peptide Letters
|September 20, 2022
Summary
Gut peptides, signaling molecules from the gut, significantly impact energy homeostasis and appetite by communicating with the brain via the gut-brain axis. Different gut peptides exert distinct effects on appetite regulation.
Area of Science:
- Endocrinology
- Neuroscience
- Gastroenterology
Background:
- Gut peptides are signaling molecules secreted by gut endocrine cells.
- These peptides play a crucial role in inter-organ communication and energy homeostasis.
- The gut-brain axis (GBA) facilitates bidirectional communication between the gut and the central nervous system (CNS).
Purpose of the Study:
- To explore the role of gut peptides in regulating appetite and energy metabolism.
- To understand the communication pathways involved in the gut-brain axis related to appetite.
- To investigate how different gut peptides influence appetite regulation.
Main Methods:
- Review of existing literature on gut peptides and their functions.
- Analysis of the mechanisms underlying gut peptide signaling.
- Examination of the role of the hypothalamus and brainstem in appetite control.
Main Results:
- Gut peptides modulate organ functions and energy metabolism.
- Appetite regulation involves complex interactions between hedonic and homeostatic factors.
- The hypothalamus, particularly the arcuate nucleus (ARC), is central to energy homeostasis and appetite control.
- Gut peptides convey peripheral energy balance information to the brain.
Conclusions:
- Gut peptides are key regulators of appetite and energy homeostasis.
- The gut-brain axis is a critical pathway for this regulation.
- Varied gut peptides exhibit distinct effects on appetite control.
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